Chronic-disease intelligence platform
Find the Drivers. Treat the Whole System.
Instead of asking only which disease you have, TOBIN HealthOS asks which biological forces are driving it — then separates exposure, association, mechanism, clinical evidence and demonstrated causation before suggesting anything.
The five TOBIN domains
0–100 scale · illustrative- T
Toxin Overload
Environmental chemicals, occupational exposures, air pollution, plastics, pesticides, solvents, metals, medications, cosmetics and food-related exposures, read alongside population biomonitoring data.
- O
Oxidative Stress
Redox imbalance, mitochondrial dysfunction, ROS/RNS burden, antioxidant capacity, metabolic stress and lipid oxidation indicators.
- B
Biological / Hormonal Imbalance
Estrogen, androgen and progesterone balance, thyroid, adrenal, insulin and leptin signaling, circadian hormones, growth factors and endocrine-active exposures.
- I
Inflammation / Infections / Immune Dysregulation
Innate and adaptive immunity, inflammatory pathways, allergy, autoimmunity, mast-cell activity, microbiome disruption and clinically relevant infections.
- N
Nutrient Deficiencies
Micronutrients, macronutrients, essential fatty acids, amino acids, minerals, vitamins, cofactors and nutrient–drug–environment interactions.
iClinical organizational scores based on the TOBIN framework. They group signals for review and are not validated diagnostic instruments or a medical diagnosis.
Start here
Patient experienceKnowledge layer: TOBINintel.org · Clinical experience layer: TOBIN HealthOS
How a finding is labeled
Evidence ladder A–EiDetection of an exposure does not establish that it caused a disease. This platform separates exposure, association, plausible mechanism, clinical evidence and demonstrated causation.
The Quadpandemics
Four analytical layersEstrogen & Endocrine Disruption
Endocrine-active chemicals are widely measurable in the population; their health effects must be evaluated exposure by exposure.
Open layerObesity & Metabolic Dysfunction
Obesity is a signaling and exposure problem, not a number on a scale.
Open layerAllergy & Immune Dysregulation
Allergic and immune-complex disease is the fastest-rising chronic burden of the century.
Open layerAnxiety, Depression & Neurobehavioral Health
Mood symptoms are assessed responsibly — never automatically attributed to toxins or hormones.
Open layerThe Fifth Estate
Host–microbe–immune ecosystem- BacteriomeGut, oral, skin, respiratory and vaginal bacterial communities and barrier function.
- ViromePersistent and reactivated viral findings, interpreted against immune status.
- MycobiomeFungal colonization, mold and water-damage history, and antifungal stewardship.
- ParasitomeClinically relevant parasitic findings and their epidemiologic plausibility.
- Microbial metabolitesSCFAs, bile acids, biofilms and metabolite signatures linked to host immunity.
iEvery microbial finding is classified as active infection, colonization, dysbiosis hypothesis, past exposure or incidental detection — so an organism is never treated simply because it was detected.
Protocol Fusion Engine
Six parallel evidence lanesConventional
Guideline-based diagnosis, medications, procedures, screening and referral.
Functional
Lifestyle and environmental assessment, metabolic relationships, nutrition, sleep and activity.
Integrative
Evidence-supported combinations of conventional and complementary care.
Orthomolecular
Nutrient optimization with dose, indication, contraindication and interaction detail.
Traditional
Traditional dietary, botanical and lifestyle approaches with explicit safety grading.
Energy / Physical
Photobiomodulation, PEMF and related modalities, only where indicated, with evidence shown.
Energy medicine partner: Tayapulse →Disease Intelligence Centers
12 openPandemic II
Obesity & Metabolic Dysfunction
Obesity is modeled as a disorder of energy signaling rather than a BMI value: endocrine-active exposures, mitochondrial and redox function, insulin, leptin, thyroid and sex-hormone signaling, adipose inflammation, microbiome relationships and nutrient adequacy are each evaluated separately.
Pandemic II
Type 2 Diabetes
Beta-cell stress is modeled as the end point of several drivers at once: glycemic load and nutrient quality, oxidative and mitochondrial stress, hormonal signaling, low-grade inflammation and selected exposures.
Pandemic III
Asthma & Allergic Airway Disease
Airway inflammation is mapped against indoor and outdoor exposures, immune phenotype, microbial ecology and nutrient status, with guideline therapy always in the foreground.
Pandemic I & II
PCOS & Hormonal Dysregulation
PCOS is approached as a metabolic–endocrine phenotype: androgen and insulin signaling, adipose inflammation, nutrient status and endocrine-active exposures are evaluated side by side.
Pandemic IV
Depressive & Anxiety Disorders
Mood symptoms are organized, not explained away. Sleep, stress, medications, endocrine factors, nutrient status, metabolic dysfunction, inflammation, substance use, social determinants and exposures are each examined as possible contributors, with validated screening and escalation built in.
Fifth Estate
IBS & Gut Barrier Dysfunction
Symptoms are mapped across diet, motility, visceral sensitivity, microbial ecology, immune activation and exposures, while red flags are routed to conventional evaluation first.
Pandemic I
Hypothyroidism & Hashimoto's Thyroiditis
Primary hypothyroidism is most often autoimmune (Hashimoto's thyroiditis). It is diagnosed by TSH with free T4, and anti-TPO antibodies identify the autoimmune form. Iodine status, selenium, iron, pregnancy and certain medications all modify thyroid function.
Pandemic II
Fatty Liver Disease (MASLD)
Metabolic dysfunction-associated steatotic liver disease (formerly NAFLD) is fat in the liver with at least one cardiometabolic risk factor. It affects about one in three adults; fibrosis stage, estimated with the FIB-4 score, drives outcomes.
Fifth Estate / N
Iron Deficiency & Anemia
Iron deficiency is the most common nutrient deficiency worldwide. Ferritin under 30 ng/mL indicates depleted stores even before anemia; hemoglobin falls later. A cause — blood loss, malabsorption (celiac, H. pylori) or low intake — should always be sought.
Pandemic II
Insulin Resistance (Prediabetes Pattern)
Insulin resistance means the body needs more insulin to keep glucose normal. It often comes years before type 2 diabetes. It is estimated with HOMA-IR = (fasting insulin µIU/mL × fasting glucose mg/dL) ÷ 405. Values of about 2.5 or more, a triglyceride/HDL ratio of 3 or more, or HbA1c of 5.7–6.4% suggest it. HOMA-IR cutoffs vary by population and assay, so it guides risk but does not diagnose.
Fifth Estate / I
Gut Dysbiosis & SIBO
Dysbiosis means an unhealthy change in gut microbes. It is a research concept, and there is no validated lab test for it. Stool microbiome panels are not recommended for diagnosis. The parts that can be measured are small-intestinal bacterial overgrowth (SIBO) and gut inflammation. SIBO is shown by a lactulose or glucose breath test with a hydrogen rise of 20 ppm or more within 90 minutes, or methane of 10 ppm or more (North American Consensus 2017). Gut inflammation is shown by fecal calprotectin above about 50 µg/g, which calls for workup to exclude inflammatory bowel disease.
Pandemic IV
HPA-Axis Dysregulation (often called "adrenal fatigue")
"Adrenal fatigue" is not a recognized diagnosis. The Endocrine Society and a 2016 systematic review found no evidence for it. TOBIN uses the term HPA-axis dysregulation for stress-related fatigue, poor sleep and low resilience, where the adrenal glands themselves are not failing. The priority is to rule out real adrenal disease. Morning serum cortisol below 3 µg/dL strongly suggests adrenal insufficiency, and a value of 15 µg/dL or more makes it unlikely (Endocrine Society 2016). Values in between need an ACTH stimulation test. Late-night salivary cortisol above the lab's limit screens for Cushing's syndrome.