TOBIN HealthOSChronic-disease intelligence

Knowledge layer

TOBIN Intelligence Library

The evidence behind every score and suggestion in TOBIN HealthOS — graded, with what is known kept separate from what is suspected.

See the five domains: definitions, scoring criteria and sources →

Disease evidence reviews

12 reviews
Obesity & Metabolic Dysfunction4 graded mechanisms · Pandemic IIType 2 Diabetes4 graded mechanisms · Pandemic IIAsthma & Allergic Airway Disease4 graded mechanisms · Pandemic IIIPCOS & Hormonal Dysregulation4 graded mechanisms · Pandemic I & IIDepressive & Anxiety Disorders4 graded mechanisms · Pandemic IVIBS & Gut Barrier Dysfunction4 graded mechanisms · Fifth EstateHypothyroidism & Hashimoto's Thyroiditis4 graded mechanisms · Pandemic IFatty Liver Disease (MASLD)4 graded mechanisms · Pandemic IIIron Deficiency & Anemia4 graded mechanisms · Fifth Estate / NInsulin Resistance (Prediabetes Pattern)4 graded mechanisms · Pandemic IIGut Dysbiosis & SIBO4 graded mechanisms · Fifth Estate / IHPA-Axis Dysregulation (often called "adrenal fatigue")4 graded mechanisms · Pandemic IV

The five TOBIN domains

  • T Toxin Overload

    Environmental chemicals, occupational exposures, air pollution, plastics, pesticides, solvents, metals, medications, cosmetics and food-related exposures, read alongside population biomonitoring data.

    Labs that move this score: ALT, GGT, Blood lead, Blood mercury

  • O Oxidative Stress

    Redox imbalance, mitochondrial dysfunction, ROS/RNS burden, antioxidant capacity, metabolic stress and lipid oxidation indicators.

    Labs that move this score: HbA1c, Fasting glucose, ApoB, Triglycerides, HDL cholesterol, ALT, GGT, Homocysteine, Reverse T3, Total cholesterol, LDL cholesterol, Non-HDL cholesterol, LDL particle number (LDL-P), Small LDL-P, LDL particle size, HDL particle number (HDL-P), Lp(a), sdLDL-C (small dense LDL), Lp-PLA2 activity, Oxidized LDL

  • B Biological / Hormonal Imbalance

    Estrogen, androgen and progesterone balance, thyroid, adrenal, insulin and leptin signaling, circadian hormones, growth factors and endocrine-active exposures.

    Labs that move this score: HbA1c, Fasting insulin, TSH, Free T4, Free T3, Reverse T3, Anti-TPO antibodies, Thyroglobulin antibodies, Small LDL-P, LDL particle size, sdLDL-C (small dense LDL)

  • I Inflammation / Infections / Immune Dysregulation

    Innate and adaptive immunity, inflammatory pathways, allergy, autoimmunity, mast-cell activity, microbiome disruption and clinically relevant infections.

    Labs that move this score: hs-CRP, Ferritin, Eosinophils (absolute), Total IgE, White blood cells, Anti-TPO antibodies, Thyroglobulin antibodies, Lp-PLA2 activity

  • N Nutrient Deficiencies

    Micronutrients, macronutrients, essential fatty acids, amino acids, minerals, vitamins, cofactors and nutrient–drug–environment interactions.

    Labs that move this score: 25-OH vitamin D, Ferritin, Vitamin B12, Magnesium (serum), Omega-3 index, Homocysteine, Free T3

Quadpandemics

  • I · Estrogen & Endocrine Disruption

    The Endocrine Exposure Intelligence Center separates three variables that are usually collapsed together: whether an exposure is detected, whether the substance has known or potential endocrine activity, and how strong the evidence is that the exposure contributes to a disease.

  • II · Obesity & Metabolic Dysfunction

    Builds a Metabolic TOBIN Map instead of a weight-loss plan: body composition and visceral adiposity alongside glucose, insulin, HbA1c, HOMA-IR, lipids, ApoB, Lp(a), liver markers, blood pressure, sleep, diet, activity, medications and exposures.

  • III · Allergy & Immune Dysregulation

    Modules for asthma, allergic rhinitis, food allergy, atopic dermatitis, urticaria, mast-cell disorders, eosinophilic disease, immune-complex conditions and selected autoimmune disorders, integrated with allergen exposure, IgE and component testing, eosinophils, tryptase where appropriate, and microbiome factors.

  • IV · Anxiety, Depression & Neurobehavioral Health

    Examines possible relationships among sleep, stress, medications, endocrine factors, nutrient deficiencies, metabolic dysfunction, inflammation, substance use, social determinants and exposures. Validated screening instruments, risk escalation and clinician referral are part of the workflow.

Fifth Estate

  • Bacteriome — Gut, oral, skin, respiratory and vaginal bacterial communities and barrier function.
  • Virome — Persistent and reactivated viral findings, interpreted against immune status.
  • Mycobiome — Fungal colonization, mold and water-damage history, and antifungal stewardship.
  • Parasitome — Clinically relevant parasitic findings and their epidemiologic plausibility.
  • Microbial metabolites — SCFAs, bile acids, biofilms and metabolite signatures linked to host immunity.

Evidence ladder

  • AMultiple high-quality guidelines or meta-analyses
  • BModerate clinical evidence
  • CPreliminary human evidence
  • DPreclinical or mechanistic evidence
  • ETraditional or theoretical evidence

iDetection of an exposure does not establish that it caused a disease. This platform separates exposure, association, plausible mechanism, clinical evidence and demonstrated causation.