Disease Explorer
Disease Intelligence Centers
Every center opens with the same structure: what the condition is, which TOBIN domains carry the most weight, the driver chain with its evidence grade, what to test, what to monitor and which interventions exist in each of the six lanes.
Pandemic II
4 driver linksObesity & Metabolic Dysfunction
Obesity is modeled as a disorder of energy signaling rather than a BMI value: endocrine-active exposures, mitochondrial and redox function, insulin, leptin, thyroid and sex-hormone signaling, adipose inflammation, microbiome relationships and nutrient adequacy are each evaluated separately.
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Pandemic II
4 driver linksType 2 Diabetes
Beta-cell stress is modeled as the end point of several drivers at once: glycemic load and nutrient quality, oxidative and mitochondrial stress, hormonal signaling, low-grade inflammation and selected exposures.
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Pandemic III
4 driver linksAsthma & Allergic Airway Disease
Airway inflammation is mapped against indoor and outdoor exposures, immune phenotype, microbial ecology and nutrient status, with guideline therapy always in the foreground.
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Pandemic I & II
4 driver linksPCOS & Hormonal Dysregulation
PCOS is approached as a metabolic–endocrine phenotype: androgen and insulin signaling, adipose inflammation, nutrient status and endocrine-active exposures are evaluated side by side.
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Pandemic IV
4 driver linksDepressive & Anxiety Disorders
Mood symptoms are organized, not explained away. Sleep, stress, medications, endocrine factors, nutrient status, metabolic dysfunction, inflammation, substance use, social determinants and exposures are each examined as possible contributors, with validated screening and escalation built in.
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Fifth Estate
4 driver linksIBS & Gut Barrier Dysfunction
Symptoms are mapped across diet, motility, visceral sensitivity, microbial ecology, immune activation and exposures, while red flags are routed to conventional evaluation first.
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Pandemic I
4 driver linksHypothyroidism & Hashimoto's Thyroiditis
Primary hypothyroidism is most often autoimmune (Hashimoto's thyroiditis). It is diagnosed by TSH with free T4, and anti-TPO antibodies identify the autoimmune form. Iodine status, selenium, iron, pregnancy and certain medications all modify thyroid function.
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Pandemic II
4 driver linksFatty Liver Disease (MASLD)
Metabolic dysfunction-associated steatotic liver disease (formerly NAFLD) is fat in the liver with at least one cardiometabolic risk factor. It affects about one in three adults; fibrosis stage, estimated with the FIB-4 score, drives outcomes.
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Fifth Estate / N
4 driver linksIron Deficiency & Anemia
Iron deficiency is the most common nutrient deficiency worldwide. Ferritin under 30 ng/mL indicates depleted stores even before anemia; hemoglobin falls later. A cause — blood loss, malabsorption (celiac, H. pylori) or low intake — should always be sought.
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Pandemic II
4 driver linksInsulin Resistance (Prediabetes Pattern)
Insulin resistance means the body needs more insulin to keep glucose normal. It often comes years before type 2 diabetes. It is estimated with HOMA-IR = (fasting insulin µIU/mL × fasting glucose mg/dL) ÷ 405. Values of about 2.5 or more, a triglyceride/HDL ratio of 3 or more, or HbA1c of 5.7–6.4% suggest it. HOMA-IR cutoffs vary by population and assay, so it guides risk but does not diagnose.
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Fifth Estate / I
4 driver linksGut Dysbiosis & SIBO
Dysbiosis means an unhealthy change in gut microbes. It is a research concept, and there is no validated lab test for it. Stool microbiome panels are not recommended for diagnosis. The parts that can be measured are small-intestinal bacterial overgrowth (SIBO) and gut inflammation. SIBO is shown by a lactulose or glucose breath test with a hydrogen rise of 20 ppm or more within 90 minutes, or methane of 10 ppm or more (North American Consensus 2017). Gut inflammation is shown by fecal calprotectin above about 50 µg/g, which calls for workup to exclude inflammatory bowel disease.
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Pandemic IV
4 driver linksHPA-Axis Dysregulation (often called "adrenal fatigue")
"Adrenal fatigue" is not a recognized diagnosis. The Endocrine Society and a 2016 systematic review found no evidence for it. TOBIN uses the term HPA-axis dysregulation for stress-related fatigue, poor sleep and low resilience, where the adrenal glands themselves are not failing. The priority is to rule out real adrenal disease. Morning serum cortisol below 3 µg/dL strongly suggests adrenal insufficiency, and a value of 15 µg/dL or more makes it unlikely (Endocrine Society 2016). Values in between need an ACTH stimulation test. Late-night salivary cortisol above the lab's limit screens for Cushing's syndrome.
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