TOBINintel
TOBINintel knowledge portal
Every TOBIN entry, opened right here in the app.
N — Nutrient Deficiencies
Micronutrients, macronutrients, essential fatty acids, amino acids, minerals, vitamins, cofactors and nutrient–drug–environment interactions.
Quadpandemic III — Allergy & Immune Dysregulation
Allergic and immune-complex disease is the fastest-rising chronic burden of the century.
Asthma & Allergic Airway Disease
Airway inflammation is mapped against indoor and outdoor exposures, immune phenotype, microbial ecology and nutrient status, with guideline therapy always in the foreground.
Fatty Liver Disease (MASLD)
Metabolic dysfunction-associated steatotic liver disease (formerly NAFLD) is fat in the liver with at least one cardiometabolic risk factor. It affects about one in three adults; fibrosis stage, estimated with the FIB-4 score, drives outcomes.
Gut Dysbiosis & SIBO
Dysbiosis means an unhealthy change in gut microbes. It is a research concept, and there is no validated lab test for it. Stool microbiome panels are not recommended for diagnosis. The parts that can be measured are small-intestinal bacterial overgrowth (SIBO) and gut inflammation. SIBO is shown by a lactulose or glucose breath test with a hydrogen rise of 20 ppm or more within 90 minutes, or methane of 10 ppm or more (North American Consensus 2017). Gut inflammation is shown by fecal calprotectin above about 50 µg/g, which calls for workup to exclude inflammatory bowel disease.
HPA-Axis Dysregulation (often called "adrenal fatigue")
"Adrenal fatigue" is not a recognized diagnosis. The Endocrine Society and a 2016 systematic review found no evidence for it. TOBIN uses the term HPA-axis dysregulation for stress-related fatigue, poor sleep and low resilience, where the adrenal glands themselves are not failing. The priority is to rule out real adrenal disease. Morning serum cortisol below 3 µg/dL strongly suggests adrenal insufficiency, and a value of 15 µg/dL or more makes it unlikely (Endocrine Society 2016). Values in between need an ACTH stimulation test. Late-night salivary cortisol above the lab's limit screens for Cushing's syndrome.