TOBINintel
TOBINintel knowledge portal
Every TOBIN entry, opened right here in the app.
I — Inflammation / Infections / Immune Dysregulation
Innate and adaptive immunity, inflammatory pathways, allergy, autoimmunity, mast-cell activity, microbiome disruption and clinically relevant infections.
Quadpandemic III — Allergy & Immune Dysregulation
Allergic and immune-complex disease is the fastest-rising chronic burden of the century.
PCOS & Hormonal Dysregulation
PCOS is approached as a metabolic–endocrine phenotype: androgen and insulin signaling, adipose inflammation, nutrient status and endocrine-active exposures are evaluated side by side.
HPA-Axis Dysregulation (often called "adrenal fatigue")
"Adrenal fatigue" is not a recognized diagnosis. The Endocrine Society and a 2016 systematic review found no evidence for it. TOBIN uses the term HPA-axis dysregulation for stress-related fatigue, poor sleep and low resilience, where the adrenal glands themselves are not failing. The priority is to rule out real adrenal disease. Morning serum cortisol below 3 µg/dL strongly suggests adrenal insufficiency, and a value of 15 µg/dL or more makes it unlikely (Endocrine Society 2016). Values in between need an ACTH stimulation test. Late-night salivary cortisol above the lab's limit screens for Cushing's syndrome.