TOBINintel
TOBINintel knowledge portal
Every TOBIN entry, opened right here in the app.
B — Biological / Hormonal Imbalance
Estrogen, androgen and progesterone balance, thyroid, adrenal, insulin and leptin signaling, circadian hormones, growth factors and endocrine-active exposures.
Obesity & Metabolic Dysfunction
Obesity is modeled as a disorder of energy signaling rather than a BMI value: endocrine-active exposures, mitochondrial and redox function, insulin, leptin, thyroid and sex-hormone signaling, adipose inflammation, microbiome relationships and nutrient adequacy are each evaluated separately.
PCOS & Hormonal Dysregulation
PCOS is approached as a metabolic–endocrine phenotype: androgen and insulin signaling, adipose inflammation, nutrient status and endocrine-active exposures are evaluated side by side.
Insulin Resistance (Prediabetes Pattern)
Insulin resistance means the body needs more insulin to keep glucose normal. It often comes years before type 2 diabetes. It is estimated with HOMA-IR = (fasting insulin µIU/mL × fasting glucose mg/dL) ÷ 405. Values of about 2.5 or more, a triglyceride/HDL ratio of 3 or more, or HbA1c of 5.7–6.4% suggest it. HOMA-IR cutoffs vary by population and assay, so it guides risk but does not diagnose.