TOBINintel
TOBINintel knowledge portal
Every TOBIN entry, opened right here in the app.
B — Biological / Hormonal Imbalance
Estrogen, androgen and progesterone balance, thyroid, adrenal, insulin and leptin signaling, circadian hormones, growth factors and endocrine-active exposures.
I — Inflammation / Infections / Immune Dysregulation
Innate and adaptive immunity, inflammatory pathways, allergy, autoimmunity, mast-cell activity, microbiome disruption and clinically relevant infections.
Quadpandemic I — Estrogen & Endocrine Disruption
Endocrine-active chemicals are widely measurable in the population; their health effects must be evaluated exposure by exposure.
Quadpandemic II — Obesity & Metabolic Dysfunction
Obesity is a signaling and exposure problem, not a number on a scale.
Quadpandemic III — Allergy & Immune Dysregulation
Allergic and immune-complex disease is the fastest-rising chronic burden of the century.
Quadpandemic IV — Anxiety, Depression & Neurobehavioral Health
Mood symptoms are assessed responsibly — never automatically attributed to toxins or hormones.
Obesity & Metabolic Dysfunction
Obesity is modeled as a disorder of energy signaling rather than a BMI value: endocrine-active exposures, mitochondrial and redox function, insulin, leptin, thyroid and sex-hormone signaling, adipose inflammation, microbiome relationships and nutrient adequacy are each evaluated separately.
Type 2 Diabetes
Beta-cell stress is modeled as the end point of several drivers at once: glycemic load and nutrient quality, oxidative and mitochondrial stress, hormonal signaling, low-grade inflammation and selected exposures.
Asthma & Allergic Airway Disease
Airway inflammation is mapped against indoor and outdoor exposures, immune phenotype, microbial ecology and nutrient status, with guideline therapy always in the foreground.
PCOS & Hormonal Dysregulation
PCOS is approached as a metabolic–endocrine phenotype: androgen and insulin signaling, adipose inflammation, nutrient status and endocrine-active exposures are evaluated side by side.
Depressive & Anxiety Disorders
Mood symptoms are organized, not explained away. Sleep, stress, medications, endocrine factors, nutrient status, metabolic dysfunction, inflammation, substance use, social determinants and exposures are each examined as possible contributors, with validated screening and escalation built in.
IBS & Gut Barrier Dysfunction
Symptoms are mapped across diet, motility, visceral sensitivity, microbial ecology, immune activation and exposures, while red flags are routed to conventional evaluation first.
Hypothyroidism & Hashimoto's Thyroiditis
Primary hypothyroidism is most often autoimmune (Hashimoto's thyroiditis). It is diagnosed by TSH with free T4, and anti-TPO antibodies identify the autoimmune form. Iodine status, selenium, iron, pregnancy and certain medications all modify thyroid function.
Iron Deficiency & Anemia
Iron deficiency is the most common nutrient deficiency worldwide. Ferritin under 30 ng/mL indicates depleted stores even before anemia; hemoglobin falls later. A cause — blood loss, malabsorption (celiac, H. pylori) or low intake — should always be sought.
Gut Dysbiosis & SIBO
Dysbiosis means an unhealthy change in gut microbes. It is a research concept, and there is no validated lab test for it. Stool microbiome panels are not recommended for diagnosis. The parts that can be measured are small-intestinal bacterial overgrowth (SIBO) and gut inflammation. SIBO is shown by a lactulose or glucose breath test with a hydrogen rise of 20 ppm or more within 90 minutes, or methane of 10 ppm or more (North American Consensus 2017). Gut inflammation is shown by fecal calprotectin above about 50 µg/g, which calls for workup to exclude inflammatory bowel disease.
HPA-Axis Dysregulation (often called "adrenal fatigue")
"Adrenal fatigue" is not a recognized diagnosis. The Endocrine Society and a 2016 systematic review found no evidence for it. TOBIN uses the term HPA-axis dysregulation for stress-related fatigue, poor sleep and low resilience, where the adrenal glands themselves are not failing. The priority is to rule out real adrenal disease. Morning serum cortisol below 3 µg/dL strongly suggests adrenal insufficiency, and a value of 15 µg/dL or more makes it unlikely (Endocrine Society 2016). Values in between need an ACTH stimulation test. Late-night salivary cortisol above the lab's limit screens for Cushing's syndrome.